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The signs and symptoms or Leaky Gut Syndrome are very similar to those of Candida Overgrowth and intestinal dysbiosis. This Syndrome indicates an advanced degeneration of the overall health and well being of the effected person. Like all disease there are beginning signs and symptoms which can progress to more complicated issues such as UC (ulcerative colitis), CD (Crohn's disease) and irritable bowel syndrome (IBS) all commonly referred to as called IBD (inflammatory bowel disease). Long term untreated conditions contribute to Lupus, Diabetes and RA (Rheumatoid Arthritis which are immune function disruptions caused by chronic intestinal inflammation.(1)

Early onset Leaky Gut symptoms:

  • Abnormal digestive problems (gas, bloating, diarrhea, constipation) called irritable bowel syndrome (IBS).
  • Exhaustion, Chronic fatigue
  • Mental fogginess, emotional ups and downs, ADHD, ADD, bipolar
  • Food allergies or food intolerances (numerous symptoms)
  • Skin issues such as red, dry, rash, eczema, acne, psoriasis

Chronic, long term, more serious Leaky Gut symptoms:

  • Respiratory problems like asthma, sinus headaches, daily mucus.
  • Muscle stiffness, soreness, pain, swelling and inflammation, fibromyalgia.
  • Joint pain, arthritis, gout.
  • Celiac disease, Lupus, Crohn's disease, Ulcerative Colitis, Diabetes


FOOD ALLERGY symptoms ranked from mild to severe.


A specific food triggers these reactions within 24 hours of eating. Most food allergy is caused by leaky gut. If you have any of these reactions, consider our IgG4+IgA specific food allergy test. (Not usually covered by your insurance, so plan to pay out of pocket). But it will give you a useful list of (1) Foods you can eat freely, (2) Foods you can eat sparingly, and (3) Foods you should never eat - at least until you heal the leaky gut.

MILD ALLERGY means the symptoms you experience tend to be uncomfortable but not severe, such as:

  • wheezing
  • mucus: throat clearing or runny nose
  • red, itchy or watery eyes
  • tingling (anywhere but usually in or around the mouth, chin, cheeks)
  • red or warm flush (anywhere but usually the face or chest)
  • physical fatigue (extending to exhaustion)
  • recurring itch
  • mental fatigue (brain fog)

MODERATE means more persistent, more frequent, lasts longer or more intense of any above plus these:

  • hives (itchy, red elevated welts or flat red splotches)
  • constipation and/or diarrhea (loose stool)
  • skin rash or red patches (eczema)
  • light-headed-ness, dizzy, spaced out
  • mild breathing difficulties
  • swelling of the lips or face
  • headache
  • forehead or behind the eyes pain
  • nausea, upset stomach
  • feel like or actual vomiting

SEVERE means a reaction known as anaphylaxis. If someone develops any of these conditions, do not hesitate to seek immediate or emergency medical treatment:

  • swelling or closing of the throat
  • shortness or intense breathing troubles
  • chest tightness,
  • rapid or abnormal pulse
  • drop or elevation of blood pressure
  • heart palpitations
  • loss of consciousness
  • break out into a sweat


(1) The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease.
Vanuytsel T1, Vermeire S1, Cleynen I1.PMID: 24868498 [PubMed] PMCID: PMC3943850 ABSTRACT: The intestinal epithelium provides the largest interface between the external environment and the host, and is thus a crucial regulation site of innate and adaptive immunity. Zonulin is one of the few known physiological mediators of paracellular intestinal permeability. It was found upregulated in different immune diseases like Celiac disease and Type 1 Diabetes (T1D). Recently, human zonulin ... is a hemoglobin-binding protein with immunomodulatory properties. Its gene harbors a common polymorphism ... shown to be overrepresented in different immune diseases like Rheumatoid Arthritis (RA), Systemic Lupus and has also been found to be more frequent in patients with IBD (UC and CD) than in healthy controls. KEYWORDS: crohn's disease; haptoglobin; inflammatory bowel disease; intestinal barrier; intestinal permeability; ulcerative colitis; zonulin/========