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What is Leaky Gut?



Leaky Gut (also called Intestinal Permeability or Hyper Permeability) is a condition when the intestinal digestive system cell wall has become damaged to the extent of excessive permeability (1).


Your digestive system (gut, bowel, intestine, GI tract) acts like a filter which allows passage of good, healthy nutrients into the blood and keeps bad, unhealthy toxins out. One of the protective mechanisms are 'tight juncture' formed between the cells. Negative influences (see our page: Causes of Leaky Gut) break these tight junctions apart (via a protein called zonulin) and allow unwanted toxins (undigested food, microbes, toxins, acids ) to move or leak into the blood stream (thus the name 'leaky gut').

Your immune system recognizes these invaders and tries to destroy them by building antibodies. An antibody, also known as an immunoglobulin (Ig), is a large Y-shape protein produced by plasma cells that is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. (2)

That immune response will show up as numerous signs and symptoms (see our page: Signs and Symptoms of Leaky Gut) and most commonly food allergies. The Repair Phase treatment for this condition begins with testing to identify then eliminate the offending foods. Proper diet is essential followed by supplement treatment therapy.

References
1. "Intestinal permeability defects: is it time to treat?" Odenwald MA, Turner JR (Sept 2013) Clin. Gastroenterol. Hepatol. 11 (9): 1075–83.doi:10.1016/j.cgh.2013.07.001.

KEYWORDS: CA-MLCK; CD; Claudin; Crohn’s disease; GVHD; Graft vs Host Disease; IBD; IBS; IL; Inflammatory Bowel Disease; Irritable Bowel Syndrome; Leaky Gut Syndrome; MLCK; Myosin Light Chain Kinase; TNF; Tight Junction; constitutively active–myosin light chain kinase; graft-versus-host disease; inflammatory bowel disease; interleukin; irritable bowel syndrome; myosin light chain kinase; tumor necrosis factor


2. Charles Janeway (2001). Immunobiology. (5th ed.). Garland Publishing. ISBN 0-8153-3642-X. (electronic full text via NCBI Bookshelf).