What is Leaky Gut?
Leaky Gut (also called Intestinal Permeability or Hyper Permeability) is a condition when
the intestinal digestive system cell wall
has become damaged to the extent of excessive permeability (1).
Your digestive system (gut, bowel, intestine, GI tract) acts like a filter
which allows passage of good, healthy nutrients into the blood and keeps bad,
unhealthy toxins out. One of the protective mechanisms are 'tight juncture'
formed between the cells. Negative
influences (see our page: Causes of Leaky Gut) break these tight junctions
apart (via a protein called zonulin) and allow unwanted toxins (undigested
food, microbes, toxins, acids ) to move or leak into the blood stream (thus the name 'leaky gut').
Your immune system recognizes these
invaders and tries to destroy them by building antibodies. An antibody, also known as an
immunoglobulin (Ig), is a large Y-shape protein produced by plasma cells that
is used by the immune system to identify and neutralize foreign objects such as
bacteria and viruses. (2)
immune response will show up as numerous signs and symptoms (see our page: Signs
and Symptoms of Leaky Gut) and most commonly food allergies. The Repair Phase treatment for this condition
begins with testing to identify then eliminate the offending foods. Proper diet is essential followed by
supplement treatment therapy.
1. "Intestinal permeability defects: is it time to treat?" Odenwald MA, Turner JR (Sept 2013) Clin.
Gastroenterol. Hepatol. 11 (9): 1075–83.doi:10.1016/j.cgh.2013.07.001.
KEYWORDS: CA-MLCK; CD; Claudin; Crohn’s disease;
GVHD; Graft vs Host Disease; IBD; IBS; IL; Inflammatory Bowel Disease;
Irritable Bowel Syndrome; Leaky Gut Syndrome; MLCK; Myosin Light Chain Kinase;
TNF; Tight Junction; constitutively active–myosin light chain kinase;
graft-versus-host disease; inflammatory bowel disease; interleukin; irritable
bowel syndrome; myosin light chain kinase; tumor necrosis factor
2. Charles Janeway (2001). Immunobiology. (5th ed.). Garland Publishing. ISBN
0-8153-3642-X. (electronic full text via NCBI Bookshelf).